Ethanol toxicity: rehabilitation of hepatic antioxidant defense system with dietary ginger

Fitoterapia. 2008 Apr;79(3):174-8. doi: 10.1016/j.fitote.2007.11.007. Epub 2007 Nov 29.

Abstract

The current investigation has been conducted to investigate the influence of ginger on hepatic antioxidant enzymes system in ethanol treated rats. Ethanol significantly decreased the superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione content while an increase of malondialdehyde (MDA) levels were estimated in the hepatic tissue. This effect was reversed by a treatment with 1% dietary ginger for 4 weeks in rats by improved antioxidant status which suggest that treatment of ginger may have protective role against the ethanol induced hepatotoxicity.

MeSH terms

  • Administration, Oral
  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology*
  • Antioxidants / therapeutic use
  • Dietary Supplements
  • Ethanol
  • Ginger*
  • Glutathione Peroxidase / biosynthesis
  • Glutathione Reductase / biosynthesis
  • Hepatitis, Alcoholic / rehabilitation*
  • Liver / drug effects*
  • Liver / enzymology
  • Male
  • Malondialdehyde / metabolism
  • Phytotherapy*
  • Rats
  • Rats, Wistar

Substances

  • Antioxidants
  • Ethanol
  • Malondialdehyde
  • Glutathione Peroxidase
  • Glutathione Reductase