TRP channels and mechanosensory transduction: insights into the arterial myogenic response

Pflugers Arch. 2008 Jun;456(3):529-40. doi: 10.1007/s00424-007-0432-y. Epub 2008 Jan 5.


Mechano-gated ion channels are implicated in a variety of key physiological functions ranging from touch sensitivity to arterial pressure regulation. Seminal work in prokaryotes and invertebrates provided strong evidence for the role of specific ion channels in volume regulation, touch sensitivity, or hearing, specifically the mechanosensitive channel subunits of large and small conductances (MscL and MscS), the mechanosensory channel subunits (MEC) and the transient receptor potential channel subunits (TRP). In mammals, recent studies further indicate that members of the TRP channel family may also be considered as possible candidate mechanosensors responding to either tension, flow, or changes in cell volume. However, contradictory results have challenged whether these TRP channels, including TRPC1 and TRPC6, are directly activated by mechanical stimulation. In the present review, we will focus on the mechanosensory function of TRP channels, discuss whether a direct or indirect mechanism is at play, and focus on the proposed role for these channels in the arterial myogenic response to changes in intraluminal pressure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arteries / metabolism*
  • Blood Pressure
  • Humans
  • Ion Channel Gating
  • Mechanotransduction, Cellular*
  • Membrane Potentials
  • Muscle, Smooth, Vascular / metabolism*
  • Regional Blood Flow
  • TRPC Cation Channels / metabolism
  • TRPM Cation Channels / metabolism
  • TRPP Cation Channels / metabolism
  • TRPV Cation Channels / metabolism
  • Transient Receptor Potential Channels / metabolism*
  • Vasoconstriction*


  • TRPC Cation Channels
  • TRPM Cation Channels
  • TRPP Cation Channels
  • TRPV Cation Channels
  • Transient Receptor Potential Channels
  • polycystic kidney disease 1 protein
  • polycystic kidney disease 2 protein
  • transient receptor potential cation channel, subfamily C, member 1