Pamidronate treatment of hypercalcemia caused by vitamin D toxicity

J Pediatr Endocrinol Metab. 2007 Nov;20(11):1241-8. doi: 10.1515/jpem.2007.20.11.1241.

Abstract

We present a 16 month-old previously healthy boy with refractory hypercalcemia due to an overdose of an over-the-counter vitamin supplement. The patient presented to the emergency department with a few weeks' history of irritability, constipation and intermittent vomiting. His serum calcium was found to be 18 mg/dl. He was first treated with intravenous fluids, furosemide and glucocorticoids without significant improvement, but became eucalcemic within 24 hours after receiving a single dose of pamidronate. This case highlights the potential danger of high dose vitamin supplements in children, and the salutary effects of treatment with bisphosphonate.

Publication types

  • Case Reports

MeSH terms

  • Bone Density Conservation Agents / therapeutic use*
  • Calcium / blood
  • Diphosphonates / therapeutic use*
  • Drug Overdose
  • Humans
  • Hypercalcemia / blood
  • Hypercalcemia / chemically induced
  • Hypercalcemia / drug therapy*
  • Infant
  • Male
  • Pamidronate
  • Treatment Outcome
  • Vitamin D / adverse effects*

Substances

  • Bone Density Conservation Agents
  • Diphosphonates
  • Vitamin D
  • Pamidronate
  • Calcium