Cerebral venous thrombosis after immune thrombocytopenic purpura and anti-D immune globulin therapy

J Child Neurol. 2008 Mar;23(3):325-30. doi: 10.1177/0883073807309251. Epub 2008 Jan 9.

Abstract

Cerebral venous thrombosis has multiple etiologies and a wide variety of clinical manifestations. This article reports on a young girl who developed cerebral venous thrombosis after intravenous anti-D immune globulin therapy for immune thrombocytopenic purpura. In this case, venous infarction was manifested by an unusual pattern of restricted diffusion limited to the corpus callosum. The cause of cerebral venous thrombosis in this patient may be related to both immune thrombocytopenia and immunoglobulin therapy.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Brain Infarction / diagnostic imaging
  • Brain Infarction / etiology*
  • Child
  • Corpus Callosum / blood supply
  • Corpus Callosum / diagnostic imaging
  • Corpus Callosum / pathology*
  • Female
  • Humans
  • Intracranial Thrombosis / diagnostic imaging
  • Intracranial Thrombosis / etiology*
  • Phlebography
  • Purpura, Thrombocytopenic, Idiopathic / complications*
  • Purpura, Thrombocytopenic, Idiopathic / drug therapy*
  • Purpura, Thrombocytopenic, Idiopathic / immunology
  • Rho(D) Immune Globulin / adverse effects*
  • Rho(D) Immune Globulin / therapeutic use

Substances

  • Rho(D) Immune Globulin