Self-assembled monolayers of an oligo(ethylene oxide) disulfide and its corresponding thiol assembled from water: characterization and protein resistance

David J Vanderah; Marlon L Walker; Mark A Rocco; Kenneth A Rubinson

doi:10.1021/la7028824

Self-assembled monolayers of an oligo(ethylene oxide) disulfide and its corresponding thiol assembled from water: characterization and protein resistance

Langmuir. 2008 Feb 5;24(3):826-9. doi: 10.1021/la7028824. Epub 2008 Jan 11.

Authors

David J Vanderah¹, Marlon L Walker, Mark A Rocco, Kenneth A Rubinson

Affiliation

¹ Biochemical Science Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, USA. david.vanderah@nist.gov

PMID: 18186657
DOI: 10.1021/la7028824

Abstract

Self-assembled monolayers (SAMs) of the disulfide [S(CH2CH2O)6CH3]2 ([S(EO)6]2) on Au from 95% ethanol and from 100% water are described. Spectroscopic ellipsometry and reflection-absorption infrared spectroscopy indicate that the [S(EO)6]2 films are similar to the disordered films of HS(CH2CH2O)6CH3 ((EO)6) and HS(CH2)3O(CH2CH2O)5CH3 (C3EO5) at their protein adsorption minima. The [S(EO)6]2 SAMs exhibit constant film thickness (d) of 1.2 +/- 0.2 nm over long immersion times (up to 20 days) and do not attain the highly ordered, 7/2 helical structure of the (EO)6 and C3EO5 SAMs (d = 2.0 nm). Exposure of these self-limiting [S(EO)6]2 SAMs to bovine serum albumin show high resistance to protein adsorption.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adsorption
Animals
Biocompatible Materials / chemistry*
Cattle
Ethylene Oxide / chemistry*
Proteins / chemistry*
Serum Albumin, Bovine / chemistry
Spectrophotometry, Infrared
Sulfhydryl Compounds / chemistry
Water

Substances

Biocompatible Materials
Proteins
Sulfhydryl Compounds
Water
Serum Albumin, Bovine
Ethylene Oxide