Role of quercetin (a natural herbal compound) in allergy and inflammation

J Biol Regul Homeost Agents. Jul-Dec 2006;20(3-4):47-52.

Abstract

An investigated flavonoid, quercetin, is reviewed in this article. Quercetin is a bioflavonoid found in red wine, grapefruit, onions, apples, black tea, and, in lesser amounts, in leafy green vegetables and beans. Quercetin has an antioxidant and anti-inflammatory activity and prevents cancer. Quercitin inhibits the growth of certain malignant cells in vitro, and histamine and most cyclin-dependent kinases and also displays unique anticancer properties. Quercetin is a natural compound that blocks substances involved in allergies and is able to act as an inhibitor of mast cell secretion, causes a decrease in the release of tryptase, MCP-1 and IL-6 and the down-regulation of histidine decarboxylase (HDC) mRNA from few mast cell lines. Quercetin is a safe, natural therapy that may be used as primary therapy or in conjunction with conventional methods.

Publication types

  • Review

MeSH terms

  • Humans
  • Hypersensitivity / metabolism
  • Inflammation / metabolism
  • Mast Cells / drug effects
  • Quercetin*
  • Tryptases*

Substances

  • Quercetin
  • Tryptases