Serum level of macrophage colony-stimulating factor is increased in prostate cancer patients with bone metastasis

Hum Cell. 2008 Feb;21(1):1-6. doi: 10.1111/j.1749-0774.2007.00042.x.


Recent evaluation of human prostate tissues has shown predominantly high expression of the macrophage colony-stimulating factor receptor in prostatic intra-epithelial neoplasia or prostate cancer. However, the expression of its ligand, the macrophage colony-stimulating factor (M-CSF), and the biological role of this signaling in prostate cancer has not been analyzed. In this research we determined the relationship of serum M-CSF level to clinical parameters of prostate cancer progression. We measured the serum level of M-CSF in 170 patients with histologically confirmed prostatic adenocarcinoma and in 54 patients in whom prostate cancer was not detected. We also investigated the M-CSF expression in prostate cancer tissues by immunohistochemistry. The serum levels of M-CSF in bone metastatic prostate cancer patients was significantly higher than those in non-metastatic patients, while M-CSF did not differ with regards to histological grade, Gleason score or local tumor progression. M-CSF expression was detected in prostate cancer cells themselves by immunohistochemistry. These results suggest that M-CSF may have a functional role in prostate cancer progression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / secondary*
  • Aged
  • Biomarkers, Tumor / analysis
  • Biomarkers, Tumor / blood
  • Bone Neoplasms / secondary*
  • Disease Progression
  • Humans
  • Immunohistochemistry
  • Macrophage Colony-Stimulating Factor / analysis
  • Macrophage Colony-Stimulating Factor / antagonists & inhibitors
  • Macrophage Colony-Stimulating Factor / blood*
  • Macrophage Colony-Stimulating Factor / physiology*
  • Male
  • Middle Aged
  • Prostatic Neoplasms / etiology*
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / therapy


  • Biomarkers, Tumor
  • Macrophage Colony-Stimulating Factor