Network homogeneity reveals decreased integrity of default-mode network in ADHD

J Neurosci Methods. 2008 Mar 30;169(1):249-54. doi: 10.1016/j.jneumeth.2007.11.031. Epub 2007 Dec 8.


Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Attention Deficit Disorder with Hyperactivity / diagnosis
  • Attention Deficit Disorder with Hyperactivity / physiopathology*
  • Brain Mapping / methods*
  • Cerebral Cortex / anatomy & histology
  • Cerebral Cortex / physiopathology*
  • Cognition / physiology
  • Evoked Potentials / physiology
  • Functional Laterality / physiology
  • Gyrus Cinguli / anatomy & histology
  • Gyrus Cinguli / physiopathology
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Nerve Net / anatomy & histology
  • Nerve Net / physiopathology*
  • Neural Pathways / anatomy & histology
  • Neural Pathways / physiopathology
  • Neuropsychological Tests
  • Parietal Lobe / anatomy & histology
  • Parietal Lobe / physiopathology
  • Psychomotor Performance / physiology
  • Signal Processing, Computer-Assisted