Abstract
A range of novel benzopyrans have been synthesised and biologically evaluated for K(ATP) channel activity employing cromakalim 1 as a benchmark K(ATP) channel opener. Although the compounds that were evaluated demonstrated a reduced ability to relax phenylephrine stimulated rat thoracic tissue, we provide evidence that benzopyrans 7a-h may be operating via an alternative mechanism than ATP-sensitive K(+) channel activity.
MeSH terms
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Animals
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Antihypertensive Agents / chemical synthesis*
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Antihypertensive Agents / chemistry
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Antihypertensive Agents / pharmacology*
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Aorta, Thoracic / drug effects
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Benzopyrans / chemical synthesis*
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Benzopyrans / chemistry
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Benzopyrans / pharmacology*
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Combinatorial Chemistry Techniques
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Cromakalim / chemistry
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Cromakalim / pharmacology
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Molecular Structure
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Muscle Relaxation / drug effects
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Myocytes, Smooth Muscle / drug effects
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Potassium Channels / agonists*
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Rats
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Structure-Activity Relationship
Substances
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Antihypertensive Agents
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Benzopyrans
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Potassium Channels
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Cromakalim