Role of the MexAB-OprM Efflux Pump of Pseudomonas Aeruginosa in Tolerance to Tea Tree (Melaleuca Alternifolia) Oil and Its Monoterpene Components terpinen-4-ol, 1,8-cineole, and Alpha-Terpineol

Appl Environ Microbiol. 2008 Mar;74(6):1932-5. doi: 10.1128/AEM.02334-07. Epub 2008 Jan 11.

Abstract

Using a series of efflux mutants of Pseudomonas aeruginosa, the MexAB-OprM pump was identified as contributing to this organism's tolerance to the antimicrobial agent tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and alpha-terpineol. These data show that a multidrug efflux system of P. aeruginosa can extrude monoterpenes and related alcohols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Outer Membrane Proteins / physiology*
  • Cyclohexane Monoterpenes
  • Cyclohexanols / chemistry
  • Cyclohexanols / pharmacology
  • Cyclohexenes / chemistry
  • Cyclohexenes / pharmacology
  • Eucalyptol
  • Melaleuca / chemistry*
  • Membrane Transport Proteins / genetics
  • Membrane Transport Proteins / physiology
  • Monoterpenes / chemistry
  • Monoterpenes / pharmacology*
  • Mutation
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / growth & development
  • Tea Tree Oil / chemistry
  • Tea Tree Oil / pharmacology*

Substances

  • Bacterial Outer Membrane Proteins
  • Cyclohexane Monoterpenes
  • Cyclohexanols
  • Cyclohexenes
  • Membrane Transport Proteins
  • MexA protein, Pseudomonas aeruginosa
  • MexB protein, Pseudomonas aeruginosa
  • Monoterpenes
  • OprM protein, Pseudomonas aeruginosa
  • alpha-terpineol
  • Tea Tree Oil
  • Eucalyptol