Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides

Nat Genet. 2008 Feb;40(2):149-51. doi: 10.1038/ng.2007.61. Epub 2008 Jan 13.

Abstract

We tested over 267,000 SNPs in 1,005 Northern Europeans and 248,000 in 1,006 Indian Asians for association with triglycerides and HDL cholesterol, with replication in 10,536 subjects. We found association of a nonsynonymous SNP (rs3812316, G771C, Gln241His) in MLXIPL with plasma triglyceride levels (combined P = 1.4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Asian Continental Ancestry Group
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics*
  • Chromosomes, Human, Pair 7
  • Cohort Studies
  • Europe
  • European Continental Ancestry Group
  • Female
  • Genetic Markers
  • Genetic Variation*
  • Genome, Human*
  • Homozygote
  • Humans
  • India
  • Linear Models
  • Linkage Disequilibrium
  • Male
  • Metabolic Syndrome / genetics
  • Mexico
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Principal Component Analysis
  • Triglycerides / blood*
  • Triglycerides / genetics*

Substances

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Genetic Markers
  • MLXIPL protein, human
  • Triglycerides