Extended and bent conformations of the mannose receptor family

Cell Mol Life Sci. 2008 May;65(9):1302-10. doi: 10.1007/s00018-007-7497-9.

Abstract

In mammals, the mannose receptor family consists of four members, Endo180, DEC-205, phospholipase A2 receptor and the mannose receptor. The extracellular domains of all these receptors contain a similar arrangement of domains in which an N-terminal cysteine-rich domain is followed by a single fibronectin type II domain and eight or ten C-type lectin-like domains. This review focuses on the three-dimensional structure of the receptors in the mannose receptor family and its functional implication. Recent research has revealed that several members of this family can exist in at least two configurations: an extended conformation with the N-terminal cysteine-rich domain pointing outwards from the cell membrane and a bent conformation where the N-terminal domains fold back to interact with C-type lectin-like domains at the middle of the structure. Conformational transitions between these two states seem to regulate the interaction of these receptors with ligands and their oligomerization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / chemistry*
  • Antigens, CD / classification
  • Lectins, C-Type / chemistry*
  • Lectins, C-Type / classification
  • Ligands
  • Mannose-Binding Lectins / chemistry*
  • Mannose-Binding Lectins / classification
  • Minor Histocompatibility Antigens
  • Protein Binding
  • Protein Structure, Tertiary
  • Receptors, Cell Surface / chemistry*
  • Receptors, Cell Surface / classification
  • Receptors, Mitogen / chemistry*
  • Receptors, Mitogen / classification
  • Receptors, Phospholipase A2 / chemistry*
  • Receptors, Phospholipase A2 / classification

Substances

  • Antigens, CD
  • DEC-205 receptor
  • Endo180
  • Lectins, C-Type
  • Ligands
  • Mannose-Binding Lectins
  • Minor Histocompatibility Antigens
  • Receptors, Cell Surface
  • Receptors, Mitogen
  • Receptors, Phospholipase A2
  • mannose receptor