Memantine and NMDA antagonism for chronic migraine: a potentially novel therapeutic approach?

Headache. 2008 Feb;48(2):284-6. doi: 10.1111/j.1526-4610.2007.01016.x. Epub 2008 Jan 8.


We present the case of a woman with chronic migraine who unexpectedly reported full remission of headache after memantine, an NMDA receptor antagonist, was administered for treating concomitant mild cognitive impairment. An underlying dose-dependent effect of memantine on headache symptoms in chronic daily headache and chronic migraine could be assumed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chronic Disease
  • Cognition Disorders / drug therapy
  • Cognition Disorders / etiology
  • Dose-Response Relationship, Drug
  • Excitatory Amino Acid Antagonists / therapeutic use*
  • Female
  • Humans
  • Memantine / therapeutic use*
  • Migraine Disorders / complications
  • Migraine Disorders / drug therapy*


  • Excitatory Amino Acid Antagonists
  • Memantine