Abstract
Wntless is a sorting receptor required for Wnt secretion. Wntless is retrieved from endosomes to the Golgi by retromer, permitting Wntless reutilization in Wnt transport. In the absence of retromer, Wntless is degraded in lysosomes and Wnt secretion is impaired.
MeSH terms
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Animals
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Endosomes / physiology*
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Golgi Apparatus / physiology*
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Models, Biological
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Signal Transduction / physiology*
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Transport Vesicles / metabolism
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Vesicular Transport Proteins / metabolism
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Wnt Proteins / metabolism*
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trans-Golgi Network / physiology*
Substances
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Vesicular Transport Proteins
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Wnt Proteins