Retromer Retrieves Wntless

Dev Cell. 2008 Jan;14(1):4-6. doi: 10.1016/j.devcel.2007.12.014.

Abstract

Wntless is a sorting receptor required for Wnt secretion. Wntless is retrieved from endosomes to the Golgi by retromer, permitting Wntless reutilization in Wnt transport. In the absence of retromer, Wntless is degraded in lysosomes and Wnt secretion is impaired.

Publication types

  • Comment

MeSH terms

  • Animals
  • Endosomes / physiology*
  • Golgi Apparatus / physiology*
  • Models, Biological
  • Signal Transduction / physiology*
  • Transport Vesicles / metabolism
  • Vesicular Transport Proteins / metabolism
  • Wnt Proteins / metabolism*
  • trans-Golgi Network / physiology*

Substances

  • Vesicular Transport Proteins
  • Wnt Proteins