p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck

Cancer Lett. 2008 May 8;263(1):26-34. doi: 10.1016/j.canlet.2007.12.011. Epub 2008 Jan 14.


The transcription factor p63 is commonly over-expressed in squamous cell carcinomas of the head and neck (SCCHN). By microarray analysis of p63-siRNA-treated SCCHN cells we identified 127 genes whose expression relies on over-expression of p63. More than 20% of these genes are involved in cell motility. Chromatin immunoprecipitation and reporter assay revealed PAI-1 and AQP3 as direct p63 transcriptional targets. In addition to PAI-1, most of the key cell motility-related molecules are up-regulated by p63, such as MMP14 and LGALS1. Our findings indicate a contribution by p63 in cell invasion and migration, supporting an oncogenic role for p63 in SCCHN.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Carcinoma, Squamous Cell / pathology*
  • Cell Line, Tumor
  • Chromatin Immunoprecipitation
  • DNA-Binding Proteins / physiology*
  • Head and Neck Neoplasms / pathology*
  • Humans
  • Neoplasm Invasiveness*
  • Neoplasm Metastasis*
  • Oligonucleotide Array Sequence Analysis
  • RNA, Small Interfering
  • Reverse Transcriptase Polymerase Chain Reaction
  • Trans-Activators / physiology*
  • Transcription Factors
  • Tumor Suppressor Proteins / physiology*


  • DNA-Binding Proteins
  • RNA, Small Interfering
  • TP63 protein, human
  • Trans-Activators
  • Transcription Factors
  • Tumor Suppressor Proteins