Dengue fever with ischemic stroke: a case report

Neurologist. 2008 Jan;14(1):40-2. doi: 10.1097/NRL.0b013e3180d0a391.

Abstract

Background: Dengue fever, especially dengue hemorrhagic fever, often presents with thrombocytopenia and hemorrhagic phenomenon. Neurologic manifestations are uncommon.

Review summary: We report a case of dengue fever with thrombocytopenia and ischemic stroke. Only supportive treatment was instituted. The neurologic deficits of the patient were initially progressive and then improved. The platelet count correlated well with the disease severity and the neurologic deficits. The time course was compatible with the critical stage in dengue hemorrhagic fever. Some studies show that immunomodulators or immunosuppressants may reverse thrombocytopenia such that the bleeding episodes improve rapidly.

Conclusion: Dengue fever may present as ischemic stroke.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Body Temperature / physiology
  • Brain Ischemia / diagnostic imaging
  • Brain Ischemia / etiology*
  • Brain Ischemia / pathology
  • Dengue / complications*
  • Dengue / physiopathology
  • Diagnosis, Differential
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Immunologic Factors / therapeutic use
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Middle Aged
  • Muscle Weakness / etiology
  • Muscle Weakness / physiopathology
  • Platelet Aggregation Inhibitors / therapeutic use
  • Platelet Count
  • Stroke / diagnostic imaging
  • Stroke / etiology*
  • Stroke / pathology
  • Thalamic Diseases / diagnostic imaging
  • Thalamic Diseases / etiology
  • Thalamic Diseases / pathology
  • Thalamus / blood supply
  • Thalamus / diagnostic imaging
  • Thalamus / pathology
  • Thrombocytopenia / etiology
  • Thrombocytopenia / physiopathology
  • Time Factors
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones
  • Immunoglobulins, Intravenous
  • Immunologic Factors
  • Immunosuppressive Agents
  • Platelet Aggregation Inhibitors