Fluorine in medicinal chemistry

Chem Soc Rev. 2008 Feb;37(2):320-30. doi: 10.1039/b610213c. Epub 2007 Dec 13.


It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.

Publication types

  • Review

MeSH terms

  • Chemistry, Pharmaceutical
  • Drug Design
  • Humans
  • Hydrocarbons, Fluorinated* / chemistry
  • Hydrocarbons, Fluorinated* / pharmacology
  • Molecular Structure
  • Stereoisomerism


  • Hydrocarbons, Fluorinated