Metabolism and disposition of [14C]5-amino-o-cresol in female F344 rats and B6C3F1 mice

Xenobiotica. 2008 Feb;38(2):171-84. doi: 10.1080/00498250701744666.


The metabolism and disposition of [(14)C]5-amino-o-cresol (AOC) in female F344 rats following oral, intravenous, and dermal administration and in female B6C3F1 mice following oral administration were studied. Greater than 80% of a single oral dose (4.0-357 mg kg(-1)) or intravenous dose (2.7 mg kg(-1)) was excreted in urine within 24 h. When the dosing site was protected from grooming, less than 10% of the dermal dose (2.5 and 26 mg kg(-1), rinsed off after 6 h) was absorbed within 24 h, and most of the absorbed radioactivity was excreted in urine. For the unprotected dermal dose, grooming played a major role in the absorption of AOC. Very little AOC-derived radioactivity was present in the surveyed tissues after 24 or 72 h regardless of route, dose level, or species. Five urinary metabolites were identified: 5-acetamido-1,4-dihydroxy-2-methylbenzene glucuronide, AOC O-glucuronide, AOC O-sulfate, N-acetyl-AOC O-glucuronide, and N-acetyl-AOC O-sulfate.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Carbon Radioisotopes
  • Cresols / administration & dosage
  • Cresols / pharmacokinetics*
  • Cresols / urine
  • Female
  • Mice
  • Mice, Inbred Strains
  • Rats
  • Rats, Inbred F344


  • 5-amino-o-cresol
  • Carbon Radioisotopes
  • Cresols