Improved insulin sensitivity and adiponectin level after exercise training in obese Korean youth

Obesity (Silver Spring). 2007 Dec;15(12):3023-30. doi: 10.1038/oby.2007.360.


Objective: The objective of this study was to investigate the association among adiposity, insulin resistance, and inflammatory markers [high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha] and adiponectin and to study the effects of exercise training on adiposity, insulin resistance, and inflammatory markers among obese male Korean adolescents.

Research methods and procedures: Twenty-six obese and 14 lean age-matched male adolescents were studied. We divided the obese subjects into two groups: obese exercise group (N = 14) and obese control group (N = 12). The obese exercise group underwent 6 weeks of jump rope exercise training (40 min/d, 5 d/wk). Adiposity, insulin resistance, lipid profile, hs-CRP, IL-6, TNF-alpha, and adiponectin were measured before and after the completion of exercise training.

Results: The current study demonstrated higher insulin resistance, total cholesterol, LDL-C levels, triglyceride, and inflammatory markers and lower adiponectin and HDL-C in obese Korean male adolescents. Six weeks of increased physical activity improved body composition, insulin sensitivity, and adiponectin levels in obese Korean male adolescents without changes in TNF-alpha, IL-6, and hs-CRP.

Discussion: Obese Korean male adolescents showed reduced adiponectin levels and increased inflammatory cytokines. Six weeks of jump rope exercise improved triglyceride and insulin sensitivity and increased adiponectin levels.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood*
  • Adolescent
  • C-Reactive Protein / metabolism
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Cross-Sectional Studies
  • Exercise / physiology*
  • Exercise Therapy
  • Humans
  • Insulin Resistance / physiology*
  • Interleukin-6 / blood
  • Korea
  • Male
  • Obesity / blood*
  • Obesity / physiopathology*
  • Obesity / therapy
  • Triglycerides / blood
  • Tumor Necrosis Factor-alpha / blood


  • Adiponectin
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Interleukin-6
  • Triglycerides
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein