Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats

Exerc Immunol Rev. 2007:13:76-88.


Aim: We aimed to examine the effect of Coenzyme Q10 (CoQ10) supplementation on the exhaustive exercise-induced injury and oxidative stress in skeletal muscle and liver.

Methods: Rats were divided into four groups: rest group [control (Con)-Rest; n = 6)], exercise group (Con-Ex; n = 6), rest group with CoQ10 supplement (CoQ10-Rest; n = 6), and exercise group with CoQ10 supplement (CoQ10-Ex; n = 6). The exercise groups were run on a treadmill until exhaustion. The CoQ10 supplemented groups received an oral administration of CoQ10 (300 mg kg(-1), 4 weeks). After 4 weeks, total CoQ concentration, creatine kinase (CK), glutamic-oxaloacetic transaminase (GOT), malondialdehyde (MDA), scavenging activity against reactive oxygen species [ROS; superoxide anions (O2*-) and hydroxyl radicals (HO*)] were measured.

Results: Total CoQ concentration in plasma, slow-twitch muscles (soleus and gastronemius deep portion), and liver were significantly increased by CoQ10 supplementation. Plasma CK was significantly higher in Con-Ex compared with Con-Rest, whereas there was no difference between CoQ10-Rest and CoQ10-Ex. There were no significant differences in muscle MDA in each group. Plasma GOT and liver MDA in exercise groups were significantly higher than that of rest groups, but not significantly different between CoQ10 supplemented groups and control groups. CoQ10 supplementation was not able to favorably influence ROS scavenging activity in skeletal muscle and liver.

Conclusions: These data indicated that CoQ10 supplementation increased total CoQ concentration in the slow-twitch muscles, and was useful for reducing exhaustive exercise-induced muscular injury by enhancing stabilization of muscle cell membrane.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aspartate Aminotransferases / blood
  • Aspartate Aminotransferases / metabolism
  • Body Weight
  • Coenzymes / administration & dosage
  • Coenzymes / blood
  • Coenzymes / metabolism
  • Creatine Kinase / blood
  • Creatine Kinase / metabolism
  • Exercise Test*
  • Hydroxyl Radical / metabolism
  • Lipid Peroxidation / physiology
  • Liver / drug effects
  • Liver / injuries
  • Liver / physiopathology
  • Male
  • Muscles / drug effects*
  • Muscles / injuries*
  • Muscles / physiopathology
  • Rats
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / blood
  • Ubiquinone / metabolism


  • Coenzymes
  • Ubiquinone
  • Hydroxyl Radical
  • Aspartate Aminotransferases
  • Creatine Kinase
  • coenzyme Q10