Androgen deprivation therapy for prostate cancer

Expert Opin Pharmacother. 2008 Feb;9(2):211-28. doi: 10.1517/14656566.9.2.211.


Androgen deprivation continues to play a crucial role in the treatment of advanced and metastatic prostate cancer. In the 65 years since its use was first described, urologists and medical oncologists have developed new and innovative ways to manipulate the hypothalamic-pituitary-gonadal axis with the goal of alleviating symptoms and prolonging the life of men with prostate cancer. Despite the successes that androgen deprivation therapy has brought, each method and regimen possesses unique benefits and burdens, of which the clinician and patient must be cognizant. This review discusses the first-line androgen deprivation methods and regimens presently in use with special attention paid to their side effects and the management of them, as well as the question of when to initiate androgen deprivation therapy.

Publication types

  • Review

MeSH terms

  • Androgen Antagonists / metabolism
  • Androgen Antagonists / therapeutic use*
  • Androgens / metabolism*
  • Animals
  • Humans
  • Male
  • Orchiectomy / methods
  • Prostatectomy / methods
  • Prostatic Neoplasms / drug therapy*
  • Prostatic Neoplasms / metabolism*
  • Prostatic Neoplasms / surgery


  • Androgen Antagonists
  • Androgens