Amplitude-integrated electroencephalographic changes in a newborn induced by overdose of morphine and corrected with naloxone

Acta Paediatr. 2008 Jan;97(1):132-4. doi: 10.1111/j.1651-2227.2007.00583.x.


The amplitude-integrated electroencephalogram (aEEG) is a useful tool to assess brain function after perinatal asphyxia in term infants. We report a full-term newborn with moderate perinatal asphyxia, who accidentally received an overdose of morphine (5000 microg/kg). The overdose of morphine resulted in a clear and immediate change of aEEG background activity from a continuous (C) to discontinuous (DC) background pattern. After administration of naloxone, the background activity restored immediately to continuous background pattern. The aEEG was used to monitor the stepwise reduction in continuous naloxone infusion.

Conclusion: An overdose of morphine leads to clear and immediate changes in aEEG which restore after naloxone treatment. The aEEG can be used to monitor naloxone infusion.

Publication types

  • Case Reports

MeSH terms

  • Analgesics, Opioid / poisoning*
  • Brain / drug effects
  • Drug Overdose / diagnosis
  • Drug Overdose / drug therapy
  • Electroencephalography*
  • Humans
  • Infant, Newborn
  • Male
  • Morphine / poisoning*
  • Naloxone / therapeutic use*
  • Narcotic Antagonists / therapeutic use*


  • Analgesics, Opioid
  • Narcotic Antagonists
  • Naloxone
  • Morphine