Hyperhomocysteinemia and recurrent carotid stenosis

BMC Cardiovasc Disord. 2008 Jan 17:8:1. doi: 10.1186/1471-2261-8-1.


Background: Hyperhomocysteinemia has been identified as a potential risk for atherosclerotic disease in epidemiologic studies. This study investigates the impact of elevated serum homocysteine on restenosis after carotid endarterectomy (CEA).

Methods: In a retrospective study, we compared fasting plasma homocysteine levels of 51 patients who developed restenosis during an eight year period after CEA with 45 patients who did not develop restenosis. Restenosis was defined as at least 50% stenosis and was assessed by applying a routine duplex scan follow up investigation. Patients with restenosis were divided into a group with early restenosis (between 3 and 18 months postoperative, a total of 39 patients) and late restenosis (19 and more months; a total of 12 patients).

Results: The groups were controlled for age, sex, and risk factors such as diabetes, nicotine abuse, weight, hypertension, and hyperlipidemia. Patients with restenosis had a significant lower mean homocysteine level (9.11 micromol/L; range: 3.23 micromol/L to 26.49 micromol/L) compared to patients without restenosis (11.01 miccromol/L; range: 5.09 micromol/L to 23.29 micromol/L; p = 0.03). Mean homocysteine level in patients with early restenosis was 8.88 micromol/L (range: 3.23-26.49 micromol/L) and 9.86 micromol/L (range 4.44-19.06 micromol/L) in late restenosis (p = 0.50).

Conclusion: The finding suggests that high plasma homocysteine concentrations do not play a significant role in the development of restenosis following CEA.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Carotid Stenosis / blood*
  • Carotid Stenosis / diagnostic imaging
  • Carotid Stenosis / surgery*
  • Case-Control Studies
  • Constriction, Pathologic
  • Endarterectomy, Carotid / adverse effects*
  • Endarterectomy, Carotid / methods
  • Female
  • Follow-Up Studies
  • Homocysteine / blood*
  • Humans
  • Hyperhomocysteinemia / complications
  • Hyperhomocysteinemia / diagnosis*
  • Male
  • Middle Aged
  • Probability
  • Recurrence
  • Reference Values
  • Retrospective Studies
  • Risk Assessment
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Sex Factors
  • Ultrasonography, Doppler, Duplex


  • Biomarkers
  • Homocysteine