RETRACTED: Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis

Life Sci. 2008 Feb 13;82(7-8):348-58. doi: 10.1016/j.lfs.2007.11.006. Epub 2007 Nov 28.


This article has been retracted: please see Elsevier Policy on Article Withdrawal ( This article has been retracted at the request of the Editor-in-Chief. Multiple figures in this article appear to be falsified/fabricated, and can not be verified as the corresponding author does not have the original data. Figure 2. It appears that data has been duplicated in panels V and VI. Figure 3A. Lanes II and VI in the p53 wild band appear to be duplicated. Figure 4A. Lanes I, II, V and VI of the Beta-actin blot appear to be the same data replicated. Figure 4B. The representative blots in the Bcl-2 band, lanes V and VI are identical, as are all lanes in the Beta-actin band. Figure 5B. Lanes III and IV of the Apaf 1 band, when rotated and vertically stretched, are duplicated and appear in Figure 3D as lanes III and IV of the Cytochrome C blot in “Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways.” Pharmaceutical Research (2009). Doi: 10.1007/s11095-008-9723-z. Figure 5C. Lanes II and V of the Caspase 9 band appear to be duplicated. Figure 5E. The bands in lane V and VI of the Beta-actin blot are duplicated. Figure 5B and 5C. The Beta-actin lane IV band in 5B and lane IV in 5C appear to be duplicated from Figure 6B in “Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice.” Molecular Nutrition & Food Research (2007). Doi: 10.1002/mnfr.200600113.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene / metabolism
  • Animals
  • Anticarcinogenic Agents / therapeutic use*
  • Antioxidants / therapeutic use*
  • Apoptosis / drug effects*
  • Apoptotic Protease-Activating Factor 1 / metabolism
  • Carcinogens
  • Chemoprevention
  • Cytochromes c / metabolism
  • Disease Models, Animal
  • In Situ Nick-End Labeling
  • Male
  • Mice
  • Mitochondria / drug effects*
  • Mitochondria / metabolism
  • Poly(ADP-ribose) Polymerases / metabolism
  • Proto-Oncogene Proteins c-bcl-2
  • Resveratrol
  • Skin / drug effects*
  • Skin / metabolism
  • Skin / pathology
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / pathology
  • Skin Neoplasms / prevention & control*
  • Stilbenes / therapeutic use*
  • Tetradecanoylphorbol Acetate
  • bcl-2-Associated X Protein / metabolism


  • Anticarcinogenic Agents
  • Antioxidants
  • Apaf1 protein, mouse
  • Apoptotic Protease-Activating Factor 1
  • Carcinogens
  • Proto-Oncogene Proteins c-bcl-2
  • Stilbenes
  • bcl-2-Associated X Protein
  • 9,10-Dimethyl-1,2-benzanthracene
  • Cytochromes c
  • Poly(ADP-ribose) Polymerases
  • Tetradecanoylphorbol Acetate
  • Resveratrol