Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome

J Physiol. 2008 Mar 15;586(6):1503-8. doi: 10.1113/jphysiol.2008.150722. Epub 2008 Jan 17.


Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of fragile X and related disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / metabolism*
  • Brain / pathology*
  • Fragile X Syndrome / metabolism*
  • Fragile X Syndrome / pathology*
  • Mice
  • Mice, Knockout
  • Neurons / metabolism*
  • Neurons / pathology*
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate / metabolism*


  • Grm5 protein, mouse
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate