The state of innovation in drug development

Clin Pharmacol Ther. 2008 Feb;83(2):227-30. doi: 10.1038/sj.clpt.6100479.


The pharmaceutical industry is facing tremendous pressure, not only from payers but as a result of public perception, regulatory hurdles, and the intricacies of research and development (R&D). The latter two are significant in that they affect the number of drugs that may be registered by regulatory authorities, the time to discover and develop drugs, and the cost of drug development. Because drug development has been stagnant in terms of innovation, there exists huge potential for innovation. Failure to innovate drug development will render the "big pharma" model unsustainable.

MeSH terms

  • Animals
  • Biomedical Research* / economics
  • Biomedical Research* / legislation & jurisprudence
  • Biomedical Research* / trends
  • Diffusion of Innovation*
  • Drug Approval
  • Drug Costs
  • Drug Design*
  • Drug Industry* / economics
  • Drug Industry* / legislation & jurisprudence
  • Drug Industry* / trends
  • Humans
  • Legislation, Drug
  • Research Support as Topic
  • Technology, Pharmaceutical* / economics
  • Technology, Pharmaceutical* / legislation & jurisprudence
  • Technology, Pharmaceutical* / trends