Failure to replicate effect of Kibra on human memory in two large cohorts of European origin

Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):667-8. doi: 10.1002/ajmg.b.30658.

Abstract

It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory.

MeSH terms

  • Cohort Studies
  • Europe
  • European Continental Ancestry Group
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Memory / physiology*
  • Phosphoproteins
  • Polymorphism, Single Nucleotide
  • Proteins / genetics*
  • Proteins / physiology
  • Reproducibility of Results

Substances

  • Intracellular Signaling Peptides and Proteins
  • Phosphoproteins
  • Proteins
  • WWC1 protein, human