Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp

J Am Chem Soc. 2008 Feb 13;130(6):1806-7. doi: 10.1021/ja7110064. Epub 2008 Jan 19.
No abstract available

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Proliferation / drug effects*
  • Chromatography, High Pressure Liquid / methods
  • Cyanobacteria / chemistry*
  • Depsipeptides / chemistry*
  • Depsipeptides / isolation & purification
  • Depsipeptides / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Epithelial Cells / drug effects
  • Fibroblasts / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy / methods
  • Magnetic Resonance Spectroscopy / standards
  • Mass Spectrometry / methods
  • Mice
  • Molecular Conformation
  • NIH 3T3 Cells
  • Reference Standards
  • Thiazoles / chemistry*
  • Thiazoles / isolation & purification
  • Thiazoles / pharmacology*

Substances

  • Depsipeptides
  • Thiazoles
  • largazole