[Trimetazidine-induced encephalopathy with choreiform disorders: a case report]

Rev Med Interne. 2008 Jun;29(6):512-5. doi: 10.1016/j.revmed.2007.12.001. Epub 2008 Feb 21.
[Article in French]


Trimetazidine is known to induce parkinsonism but choreiform disorders have not yet been described with this drug. A 88-year-old patient treated with trimetazidine developed choreiform movements, gait disorders, tremor and visual hallucinations. These symptoms disappeared after drug withdrawal. Although this drug contains a piperazinic ring like other anti-dopaminergic drugs which are already known to potentially induce chorea like neuroleptics and some anti-convulsive drugs. When a patient treated with trimetazidine develops or worsens motor disorders (parkinsonism or choreiform disorders), this drug must be stopped.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged, 80 and over
  • Brain Diseases, Metabolic / chemically induced*
  • Chorea / chemically induced*
  • Eye Diseases / drug therapy
  • Humans
  • Male
  • Trimetazidine / administration & dosage
  • Trimetazidine / adverse effects*
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / adverse effects*


  • Vasodilator Agents
  • Trimetazidine