The role of angiopoietin-like proteins in angiogenesis and metabolism

Trends Cardiovasc Med. 2008 Jan;18(1):6-14. doi: 10.1016/j.tcm.2007.10.003.

Abstract

Recently, a family of proteins structurally similar to the angiogenic regulating factors angiopoietins was identified and designated "angiopoietin-like proteins" (Angptls). Encoded by seven genes, Angptls 1 to 7 all possess an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristic of angiopoietins. However, Angptls do not bind to either the angiopoietin receptor Tie2 or the related protein Tie1 and remain orphan ligands. Nonetheless, Angptls 1, 2, 3, 4, and Angptl6/angiopoietin-related growth factor function to regulate angiogenesis. Angptls 3, 4, and Angptl6/angiopoietin-related growth factor also appear to directly regulate lipid, glucose, and energy metabolism independently of angiogenic effects. Recently, several lines of evidence reveal differential roles of Angptl structural domains in both angiogenesis and metabolism. Here, we briefly review what is currently known about Angptls function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiopoietins / metabolism
  • Angiopoietins / physiology*
  • Animals
  • Energy Metabolism / physiology*
  • Fishes
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Intercellular Signaling Peptides and Proteins / physiology*
  • Mice
  • Mice, Transgenic
  • Neovascularization, Physiologic / physiology*

Substances

  • Angiopoietins
  • Intercellular Signaling Peptides and Proteins