The DVR gene family in embryonic development

Trends Genet. Nov-Dec 1991;7(11-12):408-12. doi: 10.1016/0168-9525(91)90265-r.

Abstract

The DVR gene family consists of at least 15 members, including decapentaplegic from Drosophila, Xenopus Vg1 and the mammalian bone morphogenetic protein genes, encoding secreted proteins closely related to transforming growth factor beta Genetic and biochemical evidence supports the idea that DVR proteins form part of a cascade of extracellular signalling molecules mediating inductive tissue interactions during development.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Bone Morphogenetic Protein 3
  • Bone Morphogenetic Proteins
  • Drosophila Proteins*
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics
  • Embryo, Nonmammalian / physiology
  • Embryonic Induction
  • Embryonic and Fetal Development / genetics*
  • Gastrula / physiology
  • Gene Expression Regulation
  • Insect Hormones / genetics
  • Insect Hormones / physiology*
  • Mammals / embryology
  • Mammals / genetics
  • Mesoderm*
  • Multigene Family*
  • Osteogenesis / genetics
  • Proteins / genetics
  • Proteins / physiology*
  • Signal Transduction*
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / physiology*
  • Xenopus laevis / embryology
  • Xenopus laevis / genetics

Substances

  • Bone Morphogenetic Protein 3
  • Bone Morphogenetic Proteins
  • Drosophila Proteins
  • Insect Hormones
  • Proteins
  • Transforming Growth Factor beta
  • dpp protein, Drosophila