Antiplatelet therapy in management of transient ischemic attack: overview and evidence-based rationale

J Emerg Med. 2008 May;34(4):389-96. doi: 10.1016/j.jemermed.2007.08.056. Epub 2008 Jan 18.


As many as 300,000 transient ischemic attacks (TIAs) occur in the United States each year, accounting for 0.3% of all Emergency Department visits. An under-recognized and under-treated problem, TIA is associated with up to a 10% risk of subsequent stroke within 7 days and a 25% risk of death at 1 year. Antiplatelet therapy can result in significant reductions in secondary stroke risk. However, nearly 50% of patients with TIA leave the Emergency Department without any medication. This article discusses recent results from major antiplatelet clinical trials in stroke prevention and highlights the need for appropriate and timely initiation of antiplatelet treatment in patients with TIA.

Publication types

  • Review

MeSH terms

  • Emergency Service, Hospital
  • Evidence-Based Medicine
  • Humans
  • Ischemic Attack, Transient / complications
  • Ischemic Attack, Transient / diagnosis*
  • Ischemic Attack, Transient / physiopathology
  • Middle Aged
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Prognosis
  • Risk Factors
  • Stroke / etiology
  • Stroke / mortality
  • Stroke / prevention & control*
  • Survival Rate


  • Platelet Aggregation Inhibitors