[Pulmonary function in children after neonatal meconium aspiration syndrome]

Arch Pediatr. 2008 Feb;15(2):105-10. doi: 10.1016/j.arcped.2007.10.026. Epub 2008 Jan 18.
[Article in French]


Background: Meconium aspiration syndrome is a disease of the newborn mature or post mature. The acute pulmonary consequences can be extremely severe. In the few studies of the long-term pulmonary sequelae, it seems that certain children surviving meconium aspiration syndrome keep an obstructive syndrome. The aim of our study was to assess long term respiratory residual damage from meconium aspiration syndrome.

Methods: During a seven-year period going from 1994 to 2000, we reviewed the files of children hospitalized in neonatology department of Sfax for meconium aspiration syndrome. The children who were convoked (group M: n=27), underwent spirometry, followed by an exercise stress. An age matched control group (group C: n=23) of healthy children was investigated in the same way.

Results: The group M comprised 15 boys and 12 girls aged four to 11, an average of 7+/-1.9 years. With the study of the respiratory function, we did not find an obstructive syndrome. Spirometry revealed a total pulmonary capacity in an average of 133+/-55.65% of theoretical (group M) versus 105.5+/-27.96% of theoretical (group C) (P<0,01), testifying to alveolar hyperinflation. Spirometry fulfilled 5, 10 and 15 min after exercise showed a FEV1 reduction of respectively 8.5 versus 2 (P<0.05); 9.5 versus 3 (P<0.01) and 10.5 versus 4 (P<0.05).

Conclusion: Children surviving meconium aspiration syndrome tend to develop alveolar hyperinflation and airway hyperreactivity to exercise.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Bronchial Diseases
  • Bronchial Hyperreactivity / diagnosis
  • Bronchial Hyperreactivity / etiology
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Exercise Test
  • Female
  • Follow-Up Studies
  • Forced Expiratory Volume
  • Humans
  • Infant, Newborn
  • Lung / physiology*
  • Lung / physiopathology
  • Lung Diseases / etiology*
  • Male
  • Meconium Aspiration Syndrome* / physiopathology
  • Pulmonary Alveoli / physiopathology
  • Respiratory Distress Syndrome, Newborn / etiology
  • Spirometry
  • Time Factors
  • Total Lung Capacity