Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up?

Curr Biol. 2008 Jan 22;18(2):R76-9. doi: 10.1016/j.cub.2007.11.024.


The recognition of phosphatidylserine (PS) on apoptotic cells within tissues drives both their engulfment and an accompanying anti-inflammatory and tissue restorative program. Insight into the recognition of this phospholipid signal by phagocytes is provided by papers describing three new, but completely different, PS receptors.

MeSH terms

  • Angiogenic Proteins / metabolism
  • Animals
  • Apoptosis / physiology*
  • Cell Adhesion Molecules, Neuronal / metabolism
  • Membrane Proteins / metabolism
  • Mice
  • Phagocytes / metabolism*
  • Phosphatidylserines / metabolism*
  • Receptors, Cell Surface / metabolism*


  • Adgrb1 protein, mouse
  • Angiogenic Proteins
  • Cell Adhesion Molecules, Neuronal
  • Membrane Proteins
  • Phosphatidylserines
  • Receptors, Cell Surface
  • Stab2 protein, mouse
  • TIM-4 protein, mouse
  • phosphatidylserine receptor