Organization of the Drosophila circadian control circuit

Curr Biol. 2008 Jan 22;18(2):R84-93. doi: 10.1016/j.cub.2007.11.061.


Molecular genetics has revealed the identities of several components of the fundamental circadian molecular oscillator - an evolutionarily conserved molecular mechanism of transcription and translation that can operate in a cell-autonomous manner. Therefore, it was surprising when studies of circadian rhythmic behavior in the fruit fly Drosophila suggested that the normal operations of circadian clock cells, which house the molecular oscillator, in fact depend on non-cell-autonomous effects - interactions between the clock cells themselves. Here we review several genetic analyses that broadly extend that viewpoint. They support a model whereby the approximately 150 circadian clock cells in the brain of the fly are sub-divided into functionally discrete rhythmic centers. These centers alternatively cooperate or compete to control the different episodes of rhythmic behavior that define the fly's daily activity profile.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Clocks / physiology*
  • Brain / cytology
  • Brain / metabolism
  • Brain / physiology
  • Circadian Rhythm / physiology*
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / physiology*
  • Environment
  • Glutamic Acid / metabolism
  • Light
  • Locomotion / physiology
  • Neuropeptides / metabolism
  • Temperature


  • Drosophila Proteins
  • Neuropeptides
  • Nplp1 protein, Drosophila
  • pdf protein, Drosophila
  • neuropeptide F
  • Glutamic Acid