Induction of L1 and L2 beta-lactamase production in Stenotrophomonas maltophilia is dependent on an AmpR-type regulator

Antimicrob Agents Chemother. 2008 Apr;52(4):1525-8. doi: 10.1128/AAC.01485-07. Epub 2008 Jan 22.


A divergently oriented ampR has been located upstream of blaL2 in Stenotrophomonas maltophilia. AmpR is necessary for L1 and L2 beta-lactamase induction in response to beta-lactam challenge, and activation of AmpR is sufficient to induce L1 and L2 production. L1 induction requires more activation of AmpR than does L2 induction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / metabolism*
  • Enzyme Induction*
  • Gene Expression Regulation, Bacterial*
  • Genes, Regulator
  • Humans
  • Mutation
  • Stenotrophomonas maltophilia / drug effects
  • Stenotrophomonas maltophilia / enzymology*
  • Stenotrophomonas maltophilia / genetics
  • Stenotrophomonas maltophilia / growth & development
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / genetics
  • beta-Lactams / pharmacology


  • Bacterial Proteins
  • beta-Lactams
  • AmpR protein, Bacteria
  • beta-lactamase L1
  • beta-lactamase L2
  • beta-Lactamases