Transglutaminases in vascular biology: relevance for vascular remodeling and atherosclerosis

J Vasc Res. 2008;45(4):271-8. doi: 10.1159/000113599. Epub 2008 Jan 22.


The transglutaminase (Tgase) family consists of nine known members of whom at least three are expressed in the vascular system: type 1 Tgase, type 2 Tgase and factor XIII. The cross-linking of proteins is a characteristic feature of Tgases, of well-known importance for stabilizing the blood clot and providing mechanical strength to tissues. However, recent data suggest that Tgases play a role in several other processes in vascular biology. These newly discovered areas include endothelial barrier function, small artery remodeling, and atherosclerosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Atherosclerosis / etiology
  • Blood Vessels / growth & development
  • Blood Vessels / physiology*
  • Endothelium, Vascular / physiology
  • Humans
  • Transglutaminases / physiology*


  • Transglutaminases