Dietary lignans and postmenopausal breast cancer risk by oestrogen receptor status: a prospective cohort study of Swedish women

Br J Cancer. 2008 Feb 12;98(3):636-40. doi: 10.1038/sj.bjc.6604175. Epub 2008 Jan 22.

Abstract

Among the 51,823 postmenopausal women in the Swedish Mammography Cohort, we investigated breast cancer risk in relation to the FFQ-based estimated lignan intake by oestrogen receptor (ER) and progesterone receptor (PR) subtypes. A significant 17% risk reduction for breast cancer overall in the high lignan quartile was observed, especially among PMH user (P interaction<0.010), but no heterogeneity across ER/PR subtypes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / epidemiology*
  • Cohort Studies
  • Diet*
  • Female
  • Hormone Replacement Therapy
  • Humans
  • Lignans*
  • Middle Aged
  • Neoplasms, Hormone-Dependent / epidemiology*
  • Postmenopause*
  • Prospective Studies
  • Receptors, Estrogen / metabolism*
  • Receptors, Progesterone / metabolism
  • Risk Factors
  • Sweden

Substances

  • Lignans
  • Receptors, Estrogen
  • Receptors, Progesterone