Bruce Merrifield and solid-phase peptide synthesis: a historical assessment

Biopolymers. 2008;90(3):175-84. doi: 10.1002/bip.20925.

Abstract

Bruce Merrifield, trained as a biochemist, had to address three major challenges related to the development and acceptance of solid-phase peptide synthesis (SPPS). The challenges were (1) to reduce the concept of peptide synthesis on a insoluble support to practice, (2) overcome the resistance of synthetic chemists to this novel approach, and (3) establish that a biochemist had the scientific credentials to effect the proposed revolutionary change in chemical synthesis. How these challenges were met is discussed in this article.

Publication types

  • Biography
  • Historical Article
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • History, 20th Century
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Peptides / history*
  • United States

Substances

  • Peptides

Personal name as subject

  • Bruce Merrifield