First time, low dose citalopram use-related serotonin syndrome

Neurotoxicology. 2007 Nov;28(6):1272-4. doi: 10.1016/j.neuro.2007.05.004.

Abstract

Citalopram is a very potent and highly selective inhibitor of neuronal serotonin (5-hydroxytryptamine, or 5-HT). Serotonin syndrome is a rarely observed side-effect of Citalopram use. This report discusses a case of first time, low dose citalopram use-related serotonin syndrome presenting with confusion, hyperhidrosis, hyperreflexia, myoclonus and fever.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antidepressive Agents, Second-Generation / administration & dosage
  • Antidepressive Agents, Second-Generation / adverse effects*
  • Citalopram / administration & dosage
  • Citalopram / adverse effects*
  • Confusion / chemically induced
  • Cyproheptadine / therapeutic use
  • Fever / chemically induced
  • Fluid Therapy
  • Humans
  • Hyperhidrosis / chemically induced
  • Male
  • Myoclonus / chemically induced
  • Reflex, Abnormal / drug effects
  • Selective Serotonin Reuptake Inhibitors / administration & dosage
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Serotonin Antagonists / therapeutic use
  • Serotonin Syndrome / chemically induced*
  • Serotonin Syndrome / therapy
  • Treatment Outcome

Substances

  • Antidepressive Agents, Second-Generation
  • Serotonin Antagonists
  • Serotonin Uptake Inhibitors
  • Citalopram
  • Cyproheptadine