Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice

Bull Exp Biol Med. 2007 Apr;143(4):431-3. doi: 10.1007/s10517-007-0148-1.


The effect of original nootropic preparation Noopept on learning and long-term memory was studied with BALB/c mice. Scopolamine (1 mg/kg) impaired long-term memory trace, while Noopept (0.5 mg/kg) had no significant effect. Noopept completely prevented the development of cognitive disorders induced by scopolamine (blockade of muscarinic cholinergic receptors). Our results confirmed the presence of choline-positive effect in dipeptide piracetam analogue Noopept on retrieval of learned skill of finding a submerged platform (spatial memory). We conclude that the effectiveness of this drug should be evaluated in patients with Alzheimer's disease.

MeSH terms

  • Animals
  • Dipeptides / pharmacology*
  • Male
  • Maze Learning / drug effects
  • Memory / drug effects*
  • Mice
  • Mice, Inbred BALB C
  • Neuroprotective Agents / pharmacology
  • Nootropic Agents / pharmacology
  • Scopolamine / pharmacology*
  • Space Perception / drug effects*


  • Dipeptides
  • Neuroprotective Agents
  • Nootropic Agents
  • ethyl phenylacetyl-Pro-Gly
  • Scopolamine