Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 9 (2), 99-111

Membrane Recognition by Phospholipid-Binding Domains


Membrane Recognition by Phospholipid-Binding Domains

Mark A Lemmon. Nat Rev Mol Cell Biol.


Many different globular domains bind to the surfaces of cellular membranes, or to specific phospholipid components in these membranes, and this binding is often tightly regulated. Examples include pleckstrin homology and C2 domains, which are among the largest domain families in the human proteome. Crystal structures, binding studies and analyses of subcellular localization have provided much insight into how members of this diverse group of domains bind to membranes, what features they recognize and how binding is controlled. A full appreciation of these processes is crucial for understanding how protein localization and membrane topography and trafficking are regulated in cells.

Similar articles

See all similar articles

Cited by 557 articles

See all "Cited by" articles

Publication types

LinkOut - more resources