Long-term outcomes in a prospective cohort of apprentices exposed to high-molecular-weight agents

Am J Respir Crit Care Med. 2008 Apr 15;177(8):871-9. doi: 10.1164/rccm.200707-991OC. Epub 2008 Jan 24.


Rationale: We conducted a long-term (8-yr) follow-up of 408 apprentices entering programs involving exposure to high-molecular-weight allergens.

Objectives: The objectives were to assess the frequency of new and persisting sensitization, symptoms, and bronchial hyperresponsiveness in relation with job history after ending apprenticeship and to examine characteristics significantly associated with the incidence and remission of these occupational outcomes.

Methods: A respiratory symptom questionnaire, skin prick tests with work-related allergens (laboratory animals, flour, and latex), spirometry, and methacholine challenge were administered. The association between incidence or remission of these outcomes and individual characteristics at baseline and end of apprenticeship was examined.

Measurements and main results: In subjects who at any time during follow-up held a job related to their training (78%), the incidence of sensitization, rhinoconjunctival and chest symptoms, and bronchial hyperresponsiveness at follow-up was 1.3, 1.7, 0.7, and 2.0 per 100 person-years, respectively. The remission of these outcomes acquired during apprenticeship was 18.5, 9.6, 9.6, and 12.4 per 100 person-years, respectively, in subjects no longer in a job related to training. Several clinical, immunological, and functional characteristics at baseline and acquired during apprenticeship were found to be significantly associated with the incidence and remission of the outcomes.

Conclusions: The incidence of sensitization, symptoms, and bronchial hyperresponsiveness was lower while at work than during the apprenticeship period. A high proportion of subjects in a job not related to training experienced remission of symptoms acquired during apprenticeship.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Allergens / immunology*
  • Asthma / immunology*
  • Asthma / physiopathology
  • Asthma / prevention & control
  • Bronchial Hyperreactivity / immunology*
  • Bronchial Provocation Tests
  • Female
  • Follow-Up Studies
  • Health Surveys
  • Humans
  • Hypersensitivity, Immediate / immunology*
  • Hypersensitivity, Immediate / prevention & control
  • Male
  • Occupational Diseases / immunology*
  • Occupational Diseases / prevention & control
  • Occupational Exposure / adverse effects*
  • Occupational Exposure / prevention & control
  • Rhinitis / immunology
  • Skin Tests
  • Workplace


  • Allergens