Availability of cardio-ankle vascular index (CAVI) as a screening tool for atherosclerosis

Circ J. 2008 Feb;72(2):304-8. doi: 10.1253/circj.72.304.


Background: A novel index, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta, femoral artery, and tibial artery, was recently developed by measuring brachial - ankle pulse wave velocity and blood pressure.

Methods and results: In the present study 1,014 Japanese adults from the general population were screened to clarify the correlation between CAVI and other existing markers related to atherosclerosis, including carotid intima - media thickness (CIMT) and homocysteine (HCY). CAVI was strongly associated with age in both men and women. After adjustment for age and sex, CAVI was correlated with systolic and diastolic blood pressures. In addition, CAVI was significantly correlated with total cholesterol hemoglobin A(1c) and total HCY, as well as CIMT.

Conclusion: CAVI is an appropriate screening tool for atherosclerosis, but further studies are needed to establish a convenient and effective screening system using it.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Ankle / physiopathology*
  • Arteries / physiopathology
  • Atherosclerosis / blood
  • Atherosclerosis / diagnosis*
  • Atherosclerosis / physiopathology*
  • Biomarkers / blood
  • Blood Pressure*
  • Body Weights and Measures
  • Cholesterol / blood
  • Female
  • Glycated Hemoglobin / analysis
  • Homocysteine / blood
  • Humans
  • Male
  • Mass Screening* / methods
  • Middle Aged
  • Pulse*
  • Sex Factors
  • Tunica Intima / physiopathology


  • Biomarkers
  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human
  • Homocysteine
  • Cholesterol