Atherogenic hyperlipoproteinemia induced by cholesterol feeding the Patas monkey

Biochemistry. 1976 Jul 13;15(14):2979-85. doi: 10.1021/bi00659a007.

Abstract

Patas monkeys were studied for 2 years on three dietary regimes: (1) commercial chow (control diet); (2) semipurified diet plus lard (fat-fed); and (3) semipurified diet plus lard and cholesterol (cholesterol-fed). The control and fat-fed animals had similar lipoproteins which were equivalent to the human very low density, low density (LDL), and high density lipoproteins. An additional lipoprotein referred to as LDL-II appeared to be equivalent to the human Lp(a). The cholesterol-fed animals developed accelerated atherosclerosis associated with a hypercholesterolemia which was characterized by (1) the appearance of beta-migrating lipoproteins (B=VLDL) in the d less than 1.006, (2) an increase in the intermediate lipoproteins and LDL, and (3) the appearance of LDL-II which contained a prominence of the arginine-rich apoprotein. The arginine-rich apoprotein was also a prominent component of the B-VLDL and intermediate lipoproteins. Characterization of this apoprotein revealed that it contained 11.5 mol % arginine, had a molecular weight of approximately 34 000, and coelectrophoresed with the arginine-rich apoprotein of man, dog, swine, rat, and rabbit.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acids / analysis
  • Animals
  • Apoproteins / blood
  • Cholesterol / blood
  • Cholesterol, Dietary / metabolism*
  • Diet, Atherogenic
  • Dietary Fats
  • Erythrocebus patas
  • Female
  • Haplorhini
  • Hyperlipidemias / metabolism*
  • Lipoproteins / blood
  • Lipoproteins, LDL / blood
  • Lipoproteins, VLDL / blood
  • Male
  • Sialic Acids / analysis

Substances

  • Amino Acids
  • Apoproteins
  • Cholesterol, Dietary
  • Dietary Fats
  • Lipoproteins
  • Lipoproteins, LDL
  • Lipoproteins, VLDL
  • Sialic Acids
  • Cholesterol