Aerosolized lucinactant: a potential alternative to intratracheal surfactant replacement therapy

Expert Opin Pharmacother. 2008 Feb;9(3):475-8. doi: 10.1517/14656566.9.3.475.


Background: Surfactant replacement therapy (SRT) has been demonstrated to be both safe and highly effective in the treatment of preterm infants with respiratory distress syndrome (RDS). However, administration of the various available suspensions has required endotracheal intubation and its inherent risks. Delivery of aerosolized SRT would be a laudable goal.

Objective: To review the chemistry, pharmacodynamics, clinical efficacy and safety of aerosolized lucinactant for the prevention/treatment of RDS in the preterm infant.

Methods: Laboratory and clinical experience with aerosolized lucinactant are reviewed.

Results/conclusions: Laboratory studies confirm the ability of lucinactant to withstand the aerosolization process and to maintain its biological activity. A small clinical pilot trial demonstrated safety and feasibility and provided a signal to suggest proof of concept and the justification for a larger Phase III trial.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Administration, Inhalation
  • Aerosols
  • Continuous Positive Airway Pressure
  • Drug Combinations
  • Fatty Alcohols / administration & dosage*
  • Fatty Alcohols / therapeutic use*
  • Humans
  • Infant, Newborn
  • Intubation, Intratracheal
  • Phosphatidylglycerols / administration & dosage*
  • Phosphatidylglycerols / therapeutic use*
  • Proteins / administration & dosage*
  • Proteins / therapeutic use*
  • Pulmonary Surfactants / administration & dosage*
  • Pulmonary Surfactants / therapeutic use*
  • Respiratory Distress Syndrome, Newborn / drug therapy*


  • Aerosols
  • Drug Combinations
  • Fatty Alcohols
  • Phosphatidylglycerols
  • Proteins
  • Pulmonary Surfactants
  • lucinactant