Advanced Glycation and ROS: a link between diabetes and heart failure

Curr Vasc Pharmacol. 2008 Jan;6(1):44-51. doi: 10.2174/157016108783331312.


Despite many advances achieved to date, heart failure (HF) remains a leading cause of morbidity and mortality. There is a widely-accepted consensus that HF and diabetes are strongly linked by at least 3 mechanisms: associated comorbidities, coronary atherosclerosis or a specific diabetic cardiomiopathy. For the last 2 mechanisms, advanced glycation end-products may contribute to trigger key processes relevant to HF by affecting cardiac function through cross-linking or receptor engagement. This review focuses on the main effects of advanced glycation end-products on cardiomyocytes and endothelial cell function. Some pharmacological approaches are also discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiomegaly / pathology
  • Coronary Artery Disease / pathology
  • Diabetes Complications / metabolism
  • Diabetes Mellitus / metabolism*
  • Endothelium, Vascular / physiology
  • Glycation End Products, Advanced / metabolism*
  • Heart / physiology
  • Heart Failure / complications
  • Heart Failure / metabolism*
  • Humans
  • Myocytes, Cardiac / pathology
  • Reactive Oxygen Species / metabolism*
  • Ventricular Remodeling / physiology


  • Glycation End Products, Advanced
  • Reactive Oxygen Species