Clinicopathologic correlation in IgA nephropathy

Semin Nephrol. 2008 Jan;28(1):10-7. doi: 10.1016/j.semnephrol.2007.10.011.


IgA nephropathy is the most common biopsy-proven pattern of glomerulonephritis in the world. Many factors, both clinical and histologic, have been suggested to impact on prognosis. We review the wide variations in how patients with immunoglobulin A nephropathy can present and the important differences derived from the clinical pathologic setting through the description of 4 cases. These include the clinical scenarios of modest proteinuria, acute kidney injury, and the nephrotic syndrome.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Biopsy, Needle
  • Disease Progression
  • Female
  • Glomerular Mesangium / pathology*
  • Glomerulonephritis, IGA / pathology*
  • Glomerulonephritis, IGA / physiopathology*
  • Hematuria
  • Humans
  • Male
  • Middle Aged
  • Nephrosis, Lipoid / pathology
  • Nephrotic Syndrome / pathology
  • Proteinuria