Midcycle pericoital intravaginal bee honey and royal jelly for male factor infertility

Int J Gynaecol Obstet. 2008 May;101(2):146-9. doi: 10.1016/j.ijgo.2007.11.012. Epub 2008 Jan 28.


Objective: To evaluate the efficacy of pericoital intravaginal applications of a mixture of Egyptian bee honey and royal jelly (H/RJ) in the midcycle for the treatment of infertility due to asthenozoospermia.

Methods: Sohag University Hospital and Asyut Gynecology and Infertility Clinic conducted a crossover study of 99 couples affected by asthenozoospermia. One group used midcycle pericoital vaginal applications of H/RJ and the other underwent a standard intrauterine insemination (IUI) procedure, for 3 cycles or until conception occurred for both groups. After a washout period of 2 months, the couples for whom no pregnancy occurred were crossed over.

Results: A total of 553 cycles were analyzed. There were 23 (8.1%) and 7 (2.6%) pregnancies per cycle, respectively, in the H/RJ and the IUI groups, and the difference was statistically significant (P<0.001).

Conclusion: Using H/RJ intravaginally might be a simple and reasonably effective method of treating asthenozoospermia.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Intravaginal
  • Adult
  • Asthenozoospermia / therapy*
  • Coitus*
  • Cross-Over Studies
  • Fatty Acids / administration & dosage*
  • Female
  • Honey*
  • Humans
  • Male
  • Pregnancy
  • Pregnancy Rate
  • Reproductive Techniques, Assisted*


  • Fatty Acids
  • royal jelly